PERBEDAAN PENGARUH PAPARAN MUSIK MOZART, BEETHOVEN, DAN CHOPIN SELAMA KEBUNTINGAN TERHADAP INDEKS APOPTOSIS SEL NEURON DI CEREBELLUM Rattus norvegicus BARU LAHIR
Keywords:
MUSIK MOZART, BEETHOVEN, Chopin, INDEKS APOPTOSIS SEL NEURON, Cerebellum
Abstract
The efforts that can be done to improve brain cells in the prenatal period is the provision of nutrients and good stimulation. Exposure to classical music such as Mozart, Beethoven, and Chopin music can increase the wave of brain activity. During pregnancy, Mozart music is proven to decrease the apoptosis of neuronal. Analyzing the difference of apoptosis neuronal of cerebrum and cerebellum of newborn baby of Rattus norvegicus that are exposed to the Mozart, Beethoven, and Chopin music, and that is not exposed to music during pregnancy. Laboratory experimental research, posttestonly control group design. Subjects were female pregnant Rattus norvegicus, grouped into 4 random groups: 1 control group and 3 treatments groups; with 6 samples each. Subjects were super ovulated, and 65 dB intensity of music is played for an hour at 20.00-21.00 on the subjects on 10th day of pregnancy. On 20th day of pregnancy, the mothers was dissected using SC technique. 2 heaviest newborn babies of Rattus norvegicus were taken. Statistical test concluded there was significant differences of apoptosis neuronal of cerebellum of newborn babies of Rattus norvegicus among the exposure to Mozart, Beethoven, and Chopin music, and without the exposure to music with value of p=0,033 in cerebellum. In conclution, the exposure of Mozart’s music during pregnancy perform expression of BDNF cerebellum in the offspring-rat was higher than exposed Beethoven’s music, Chopin and not exposed to music.
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Chikahisa, S, Sei H, Morishima M, Sano A. 2006. Exprosure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults. Behav Brain Res. 169(2): 312-319
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Delamasurem, S, Mehlen, P., and Ichim, G. 2012. Neutrophins and cell death, ExpCell RES. 318(11) :1221-8.
Dellman H.D., and Brown E.M. 1992. Buku Teks Histologi Veteriner 2. Universitas Indonesia Press, Jakarta.
Diamond, M.C., Scheibel A.B., Murphy G.M. and Harvey T. 1985. On the Brain of a Scientist: Albert Einstein. Experimental Neurology. 88(85):198-204.
Djohan. 2006. Terapi music, Jogjakarta: Percetakan galang press hal 4368
Donald, M. K. 1997. Analysis Suggest Nurture’s Role in IQ. The chorionic of Higher Education: Washington.
Duus, P. 1989. Cerebral cortex. In: Topical diagnosis in neurology. Stutgart Germany :263-290.
Eisenberg, L.1999. Experience, Brain and Behavior: The importance of a Head Start, Pediatrics. 103(5):1031-5.
Alonso, M., Mediana, J. H., & Pozzo, L. 2004. ERK1/2 Activation Is Necessaray for BDNF to
34
Increase Dendritic Spine Density in Hippocampal CA1 Pyramidal Neurons. Learning Memory. 172-178
Almatsier, S. 2002. Lipida. In: Prinsip Dasar Ilmu Gizi. Jakarta: Gramedia Utama Pustaka. 5176.
Andersen, N. C., Flaum, M., Swayze, V., O’Leary, D., Alliger, R., Cohen, G., Ehrhardt, J., and Yuh, W.T.C. 1993. Intelligence and Brain Structure in Normal Individuals. American Journal of Psychiatry. 150(1): 130-134.
Andriya, R. 2013. Perbandingan Indeks Apoptosis Sel Neuron Otak Anak Rattus novergicus Baru Lahir Antara yang Mendapatkan Paparan Musik Mozart Selama 30 Menit, 1 Jam, dan 2 Jam. Surabaya: Dept/SMF Obstetri dan Ginekologi RSUD Dr. Soetomo – Fakultas Kedokteran Universitas Airlangga.
Arterburn L.M., Hall B.E., and Oken H. 2006. Distribution, interconversion, dose response of n-3 fatty acids in human. Am J Clin Nutr. 83 (Suppl): 1467S76S.
Al-Qahtani, N. 2005. Foetal Response to Music and Voice. Journal of Obstetric and Gynecology. 45(5):414-417.
Bancroft, W.J. 1985. Music Therapy and Education. Journal of the society for Accelerative Learning and Teaching. 10(1):3-16.
Banerjee, A., Sanyal, S., Patranabis, A., Banajeer, K., Guhathakurta, T., and Sengupta, R. 2016. Studi on Brain Dynamic by Non Linear Analysis of Music Induced EEG Signal. Physica A. 444:110-120.
Bassano, M. 2001. Penyembuhan Melalui Musik & Warna. Alih bahasa: Dinamika Interlingua. Putra Langit. hal. 11.
Bear, M.F., Connor, B.W., and Pradiso M.A., 1996. Neuron and Glia. In neuroscience: Exploring the Brain. Williams and Wilkins: 22- 152
Becker, E. B. E., and Bonny, A. 2004. Cell cycle Regulation of Neuronal Apoptosis in Development and Disease. Progress in Neurobiology. (72nd). P: 1-25.
Binder, D.K., and Scharfman, H. E. 2004. Brain-Derived Neurotrophic Factor. Growth Factors. 22(3): 123-131.
Blum, T. 1993. Prenatal perception learning and bonding. Leonardo Publisher. pp. 247-252.
Bordner, M. 2000. Why Mozart. Universitas Of California. Discovery Channel.
Breedlove, S.M., Watson, N.V. 2004. Biological Psychology: An Introduction to Behavioral, cognitive and Clinical Neuroscience, Sevent Edition. Sinauer Associates Publisher.
Cameron, J.R., Skofronick J.G., and Grant R. M. 2006. Fisika Tubuh Manusia. Sagung Seto, Jakarta. P: 280-301
Campbell, D. 2002. Efek Mozart Memanfaatkan Kekuatan Musik Untuk Mempertajam Pikiran, Meningkatkan Kreativitas dan Menyehatkan Tubuh. Gramedia Utama. Jakarta.
Campbell, D. 2003. The Mozart Effect for Parents: Unlocking the potential of your child. Penguin publishers, New York.
Chelderon, F., and Kim, H. Y. 2004. Docosahexaenoic acid promotes neurit growth in hipocampal neurons. Journal of Neurochemistery Lippincott Williams and Wilkins. 90: 97998.
35
Carter, A. R., Chen C., Schwarts P.M., and Segal, R. A. 2002. BrainDerived Neurotropic Factor Modulates Cerebellar Plasticity and Synaptic Ultrastructure. The Journal of Neuros cience, February. 22(4):1316-1327
Colombo, J.A., Reisin, H.D., Hidalgo, J.J.M., and Rajkowska, G. 2006. Barin Res Brainresrev. 52(2): 257-263.
Chabris L. 1999. The Mind of Your Newborn Baby. Nort Atlantic Books Berkeley: California.
Chamberlain, D. B. 1998. Prenatal Stimulation: Experimental Results. Journal of Prenatal and Perinatal Psychology and Health. 15(2): 2-4.
Chao, M.V, and Bothwell, M. 2002 Neurotrophins: To Cleave or Not to Cleave. Neuron. 33: 9-12.
Charlotte, E., Mistretta, And Robert M. Bradley. 1978. Department of Oral Biology, School of Dentistry, University of Micigan, “Effect of Early Sensory Experience on Brain and Behavioral Development,” Studies on Development of Behavior and the Nervaus Sytem. Vol 4, Early Influence, Edited by Gilbert Gottlieb, Academic Press. New York. Pages 223 and 240.
Chaudhury, S., Nag T.C, Jain, S., and Wadhwa, S. 2013. Review: Role of Sound Stimulation in Reprogramming Brain Connectivity. J. Biosci. 38(3):605-614.
Chikahisa, S, Sei H, Morishima M, Sano A. 2006. Exprosure to music in the perinatal period enhances learning performance and alters BDNF/TrkB signaling in mice as adults. Behav Brain Res. 169(2): 312-319
Chouthai, Nitin S. 2003. Changes in newtrophin levels in umbilical cord blood from infants with
defferent gestational ages and clinical condition. Pediatric Research. 53(6): 965-969.
Contran, RS. 2004. Cellular Pathology: Cel Injury and Cell Death. In: Robbins Pathologic Basic of Desease. W.B Saunders, Philladelphia. (7):26-32
Craciunescu, C. N., Brown, E. C., Mar, M.-H., Albright, C, D., Nadeau, M. R., & Zeisel, S. H. 2004. Folic Acid Deficiency During Late Gestasion Decrease Progenitor Cell Folic Acid Deficienci During Late Gestation Decreases Progenitor Cell. The Journal of Nutrition. 162-166.
Cunningham, F.G., Gant N.F., and Leveno K.J. 2005. Material Physiology. Williams Obstetrics 22 Edition. Mc Graw Hill, New York. p : 121-151.
Delamasurem, S, Mehlen, P., and Ichim, G. 2012. Neutrophins and cell death, ExpCell RES. 318(11) :1221-8.
Dellman H.D., and Brown E.M. 1992. Buku Teks Histologi Veteriner 2. Universitas Indonesia Press, Jakarta.
Diamond, M.C., Scheibel A.B., Murphy G.M. and Harvey T. 1985. On the Brain of a Scientist: Albert Einstein. Experimental Neurology. 88(85):198-204.
Djohan. 2006. Terapi music, Jogjakarta: Percetakan galang press hal 4368
Donald, M. K. 1997. Analysis Suggest Nurture’s Role in IQ. The chorionic of Higher Education: Washington.
Duus, P. 1989. Cerebral cortex. In: Topical diagnosis in neurology. Stutgart Germany :263-290.
Eisenberg, L.1999. Experience, Brain and Behavior: The importance of a Head Start, Pediatrics. 103(5):1031-5.
Published
2019-11-27
Section
Articles
