EFEKTIFITAS VAKSINASI HUMAN PAPILLOMAVIRUS (HPV) DALAM MENCEGAH KEJADIAN KANKER SERVIKS (REVIEW LITERATUR

Maria Lupita Nena Meo

doi:10.36089/job.v14i4.1129

Maria Lupita Nena Meo Universitas Sam Ratulangi

DOI: https://doi.org/10.36089/job.v14i4.1129

Keywords: Effectiveness, Vaccination, HPV, Cancer, Cervix

Abstract

Cervical cancer accounts for 8.8% of cancer deaths in Indonesia, making it the second leading cause of cancer deaths. The World Health Organization has recommended the human papillomavirus (HPV) vaccination as a preventive measure against cervical cancer. This review aims to provide an evidence-based summary of the effectiveness of HPV vaccination. Literature study on English-language articles collected from the online database PubMed, Google Scholars, and DOAJ with search keywords "Human Papillomavirus Vaccine" and "Cervical Cancer." The results of the selected articles obtained were five articles published in the last five years. The main findings from all studies consistently report that the incidence of pre-cancer and cervical cancer cases is lower in the female population who received the vaccination than in the female population who have not received the HPV vaccination. Other findings also show that the first dose of HPV vaccination is effectively given at the age of under 20 years and is very effective as a prophylaxis to suppress cervical cancer recurrence. The results of this literature review can be used as a basis for increasing the promotion and awareness of HPV vaccination in women of childbearing age so that it can reduce the incidence of cervical cancer.

References

Acuti Martellucci, C., Nomura, S., Yoneoka, D., Ueda, P., Brotherton, J. M. L., Canfell, K., Palmer, M., Manzoli, L., Giorgi Rossi, P., De Togni, A., Palmonari, C., Califano, A., Saito, E., Hashizume, M., & Shibuya, K. (2021). Human papillomavirus vaccine effectiveness within a cervical cancer screening programme: cohort study. BJOG: An International Journal of Obstetrics and Gynaecology, 128(3), 532–539. https://doi.org/10.1111/1471-0528.16429

Chen, M., Li, C., Cui, Q., Zhou, C., Chen, P., & Yao, S. (2023). The efficacy of human papillomavirus prophylactic vaccination after conization in preventing cervical intraepithelial neoplasia recurrence : A prospective observational study in China. European Journal of Obstetrics & Gynecology and Reproductive Biology, 286(December 2022), 10–15. https://doi.org/10.1016/j.ejogrb.2023.04.014

Kjaer, S. K., Dehlendorff, C., Belmonte, F., & Baandrup, L. (2021). Real-World Effectiveness of Human Papillomavirus Vaccination against Cervical Cancer. Journal of the National Cancer Institute, 113(10), 1329–1335. https://doi.org/10.1093/jnci/djab080

Lei, J., Ploner, A., Elfström, K. M., Wang, J., Roth, A., Fang, F., Sundström, K., Dillner, J., & Sparén, P. (2020). HPV Vaccination and the Risk of Invasive Cervical Cancer. New England Journal of Medicine, 383(14), 1340–1348. https://doi.org/10.1056/nejmoa1917338

Li Dong, Mari Nygard Nathalie C Stoer, Ole Klung Soyr, B. T. H. (2023). Real‐world effectiveness of HPV vaccination against cervical neoplasia among birth.pdf. Intl Journal of Cancer.

Lowy, D. R., & Schiller, J. T. (2006). Prophylactic human papillomavirus vaccines. Journal of Clinical Investigation, 116(5), 1167–1173. https://doi.org/10.1172/JCI28607

Okunade, K. S. (2020). Human papillomavirus and cervical cancer. Journal of Obstetrics and Gynaecology, 40(5), 602–608. https://doi.org/10.1080/01443615.2019.1634030

Rader, J. S., Tsaih, S. W., Fullin, D., Murray, M. W., Iden, M., Zimmermann, M. T., & Flister, M. J. (2019). Genetic variations in human papillomavirus and cervical cancer outcomes. International Journal of Cancer, 144(9), 2206–2214. https://doi.org/10.1002/ijc.32038

WHO. (2022). Cervical Cancer. WHO. https://www.who.int/news-room/fact-sheets/detail/cervical-cancer

Xing, B., Guo, J., Sheng, Y., Wu, G., & Zhao, Y. (2021). Human Papillomavirus-Negative Cervical Cancer: A Comprehensive Review. Frontiers in Oncology, 10(February), 1–8. https://doi.org/10.3389/fonc.2020.606335
.