PENGARUH EKSTRAK DAUN KETEPENG CINA (Cassia alata L.) TERHADAP KADAR GLUKOSA DARAH HEWAN COBA (Rattus norvegicus strain wistar) MODEL DM

Sabrina Salsabilah; Mustika Sari; Muthmainnah J. Abdullah; Tutun Kurniati; Emy Izzati; I Putu Sudayasa

doi:10.36089/nu.v14i4.1607

Sabrina Salsabilah Program Studi Kedokteran Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
Mustika Sari Program Studi Kedokteran Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
Muthmainnah J. Abdullah Program Studi Kedokteran Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
Tutun Kurniati Program Studi Kedokteran Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
Emy Izzati Program Studi Farmasi Fakultas Farmasi Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia
I Putu Sudayasa Bagian Ilmu Kesehatan Masyarakat-Kedokteran Komunitas Fakultas Kedokteran Universitas Halu Oleo, Kendari, Sulawesi Tenggara, Indonesia

DOI: https://doi.org/10.36089/nu.v14i4.1607

Keywords: Antidiabetic, Candle bush leaves, Cassia alata L., Blood glucose levels, Diabetes mellitus

Abstract

Candle bush (Cassia alata L.) are plants that are rich in antioxidants. There have been many studies that discuss the efficacy of Candle bush (Cassia alata L.) in skin diseases, but there is still less research that discusses the potential of Candle bush leaves as antidiabetics. Therefore, researchers want to test the effectiveness of Candle bush leaves (Cassia alata L.) in improving blood glucose levels (antidiabetic) using experimental animals (Rattus norvegicus strain wistar) induced with Streptozotosin (STZ). Candle bush leaf extract (Cassia alata L.) was made with maceration method using ethanol 70% solution. Experimental animals were divided into 6 groups. Group 1,2, and 3 are the control group, Group 4,5, and 6 are the groups that are given the extract with different doses each. This study proves that extract of Candle bush leaf (Cassia alata L.) can improve blood glucose levels of the experimental animals (Rattus norvegicus strain wistar).